![]() CSVD accounts for 50–70% of vascular cognitive impairment cases and 45% of dementia cases and results in a heavy social burden ( 2).Ĭhronic insomnia, the most common sleep disorder in elderly individuals, is often comorbid with physical diseases including cerebral vascular disease ( 3). Considering the high incidence of insomnia in CSVD patients, the results of this preliminary study support the use of low-dose trazodone to deal with insomnia and cognitive impairment in CSVD.Ĭerebral small vessel disease (CSVD) refers to the syndrome of clinical, cognitive, imaging, and pathological manifestations caused by various small vascular diseases ( 1), among which arteriosclerotic CSVD is the most common type ( 1). The improvement of cognition could be achieved by alleviation of insomnia severity. The improvement of sleep quality was correlated with increased concentration and recall abilities.Ĭonclusions: A low dose of trazodone seems acceptable and effective in reducing insomnia severity and improving concentration and recall abilities in this pilot study. ![]() Results: Trazodone caused significantly better improvements in concentration and recall abilities, measured with MoCA, as well as in PSG parameters such as sleep efficiency, N3 sleep ratio, and sleep continuity than the placebo, with no significant differences in the occurrence of side effects. Secondary outcomes included sleep parameters measured with polysomnography (PSG) and the Pittsburgh Sleep Quality Index. The primary outcome was the cognitive score on the Montreal Cognitive Assessment scale (MoCA). Participants were randomized individually to receive either trazodone (study group) or a placebo (control group) for 4 weeks. Forty patients suffering from arteriosclerotic CSVD and insomnia were recruited from an outpatient clinic. Methods: This was a randomized, double-blind, placebo-controlled pilot study. This study was performed to explore the effects of trazodone on sleep quality and cognitive function in CSVD comorbid with chronic insomnia. Low-dose trazodone is effective in treating insomnia, but it is unclear whether it can also improve cognitive function in CSVD patients.
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