![]() ![]() ![]() You know, like a normal, mere mortal does.įergie has retired, Jose Mourinho has been around everywhere in Europe and his powers are fading. Guardiola is at the very top of his game and – somehow – only appears to be getting better whilst everyone else in the management game appears to go through ebbs and flows. If you’re holding out, waiting for that to become a reality, you’re unfortunately going to be waiting a while. Cold, hard results – behind a laptop screen. No total football, no transfer war chests, no room to hide behind dodgy touchline attire down there. Would like to see how he does on Football Manager with a shoestring budget in the National League North, that’s for sure. How can someone be that good at football management? Makes you sick. He then proved ousting Sir Alex Ferguson in a European final wasn’t a fluke, doing it again two years later. It was worryingly apparent when he burst onto the scene at Barcelona in 2008-09 and led them to a treble in his first season. ![]() The former Barca boss has unlocked new levels, continually adapting his methods and seamlessly tweaking his squad to bring it to its latest, most dangerous iteration – all while sweeping up major honours along the way. Since his 2016 arrival, Guardiola has gone from strength to strength in Manchester. Not only has he now won the second continental treble of his career, he has revolutionised a club who never thought they’d have a chance of winning won, or be the poster example for how other clubs should aim to play football. And Guardiola deserves his flowers for that. Sarcasm and scepticism aside, regardless of how City got there, they did. If you can look passed the – alleged – years of financial inflation, state ownership and rampant spending in order to build a super-team since Pep’s arrival, it really is a dream come true. Pep Guardiola continues to force his way into the conversation of greatest football manager of all time, strengthening his case by leading Manchester City to a historic continental treble. ![]()
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![]() ![]() ![]() We just cut like a little scratch vocal and we took it back to LA. We were just vibing on it and the melody was sick. So we did that, and Joey Bada$$ was in there. He’s a really young guy, and a really talented producer. He played the beat and it was incredible. Some kid came in, and I guess he was in the session next door and he was like, ‘Hey? Can I play you some beats?’ I’m like, ‘I guess so.’ You know, I’m a nice guy, I like music. In an interview with Billboard Magazine, Post Malone told the story of the song, he said: “I was in New York, and we were at Quad Studios. Todd Williamson/Bravo via Getty Images Sandoval and Leviss had an affair while he was dating Ariana Madix.This song is about sex, drugs and rock ‘n’ roll lifestyle. Schwartz recently said he felt “used” and “exploited” by Sandoval. ![]() … He needs to lose the ego, he needs a change of heart, humility and to say ‘I’m sorry’ - not ‘I’m sorry, but…’” Schwartz continued. “I know Tom is itching to tell more of his side of the story, but when you have a full-blown affair, your side of the story becomes obsolete. ![]() Schwartz added that he felt like Sandoval “exploited” their friendship amid the latter’s affair with Leviss, 28, and turned him into an “unfortunate confidant.” Ariana Madix rips ‘subhuman’ Raquel, ‘rat’ Sandoval in ‘Pump Rules’ reunion trailer.How Ariana Madix found out about Tom Sandoval, Raquel Leviss’ affair.Tom Sandoval, Raquel Leviss, Ariana Madix drama, explained.… I’m taking a break from Tom right now.”įollow Page Six’s coverage of ‘Scandoval’: “He made a big mess, and he left it for us to clean up,” Schwartz said on the June 7 episode of the “When Reality Hits with Jax and Brittany” podcast. “It’s hard for me not to be resentful of him. Sandoval and Schwartz’s friendship became complicated when Sandoval confided in Schwartz about his months-long affair with Raquel Leviss. Last month, he dissed Raquel Leviss, with whom he had a months-long affair, by singing, “Schwartz’s mom has got it going on / She’s all I want, and I wait for so long / Schwartzy, can’t you see that Raquel is not for me?”īut the wannabe rock star’s latest modification notably came just over a week after Schwartz publicly said he felt “used” by his pal and business partner for dragging him into the Scandoval drama after Sandoval confided in him. This is not the first time that Sandoval has changed the lyrics to “Stacy’s Mom.” bristiananicole/Instagram “Schwartzy, do you remember when you had a lawn? / A homeowner lawn,” Sandoval sang. Tom Sandoval shaded his best friend Tom Schwartz for not being a “homeowner” anymore during a concert on Friday. Sandoval, 40, was referring to the California home that Schwartz, also 40, used to share with his ex-wife, Katie Maloney, before they sold it last summer amid their divorce. “Schwartzy, do you remember when you had a lawn? / A homeowner lawn / Your mom came out wearing just a TomTom hoodie and thong,” the frontman sang alongside his bandmates in a video he reposted on his Instagram Story. Sandoval was singing Fountains of Wayne’s hit song “Stacy’s Mom” during his struggling cover band Tom Sandoval & The Most Extras’ concert in Fresno, Calif., on Friday when he suddenly changed the lyrics. Tom Sandoval shaded his best friend Tom Schwartz after the latter said he was “taking a break” from the former amid Scandoval. Tom Schwartz: Scandoval is ‘a terrifying monster that’s taken on a life of its own’ ![]() ![]() Tip-off is set for 8 p.m.įor more information, visit the Bison Athletics website at TAIEX closed higher yesterday on the back of buying spurred by Friday’s gains on US markets, which rose following better-than-expected jobs data for last month. where the Southern Illinois Salukis awaits. HU continues its road swing in Carbondale, Ill. "Tonight, we were able to get an early statement game that validates the progress we are making on the court." ![]() "We're doing things the right way with focusing on being great students first," Nickelberry concluded. Pipkins posted a team-best 18 points while Laurent netted 16 points in a losing effort. ![]() "I'm proud of this group of young men and coaches."įor UMass (2-2), Luwane Pipkins and Jonathan Laurent had double-figure outputs. "We got out fast with scoring from Williams and Cole and controlled the rebounding all night with Savior and Cousins," Nickelberry added. Howard eclipsed 50-perfect (14-of-28) from the floor, including 6-of-12 from long range, whereas UMass shot under 27-percent 8-of-30) from the field. HU dominated the glass, outrebounding the Minutemen, 46-33, but the biggest difference was shooting in the first half. Off the bench, Cousins contributed with six boards, five points, and two dimes in the victory. "The trio of freshman big guys with Cousins has been a huge asset as well." " Lott has given us another all league type of guard that can do a lot of things," Nickelberry continued. Freshman center Akuwovo Ogheneyole (Delta State, Nigeria) recorded his first career double-double with 14 rebounds (game-high) and 11 points in the win. Redshirt guard Chad Lott (Shreveport, La.) is among those new pieces, registering 12 points and seven boards in 29 minutes of action. "We added some pieces around Cole and Williams that has helped elevate our play on court." "We knew going in we had a good team," said Howard Men's Basketball head coach Kevin Nickelberry. Cole had 17 points after going a perfect 8-of-8 from the charity stripe while the Virginia product posted a game-high 19 points on 5-of-7 shooting behind the arc. Guards RJ Cole (Union, N.J.) and Charles Williams (Richmond, Va.) combined for 36 points in the win. With the victory, HU (4-0) remains unbeaten after four games in the books this season. The game was part of the Las Vegas Holiday Invitational. (November 16, 2018) – Despite entering Friday's contest as a double-digit underdog, the Howard University Men's Basketball team beat the odds and upended UMass, 68-63, inside the Mullins Center. Basketball Basketball: Schedule Basketball: Roster Basketball: News Cross Country Cross Country: Schedule Cross Country: Roster Cross Country: News Football Football: Schedule Football: Roster Football: News Golf Golf: Schedule Golf: Roster Golf: News Soccer Soccer: Schedule Soccer: Roster Soccer: News Swimming and Diving Swimming and Diving: Schedule Swimming and Diving: Roster Swimming and Diving: News Tennis Tennis: Schedule Tennis: Roster Tennis: News Track and Field Track and Field: Schedule Track and Field: Roster Track and Field: News Basketball Basketball: Schedule Basketball: Roster Basketball: News Bowling Bowling: Schedule Bowling: Roster Bowling: News Cross Country Cross Country: Schedule Cross Country: Roster Cross Country: News Golf Golf : Schedule Golf : Roster Golf : News Lacrosse Lacrosse: Schedule Lacrosse: Roster Lacrosse: News Soccer Soccer: Schedule Soccer: Roster Soccer: News Softball Softball: Schedule Softball: Roster Softball: News Swimming and Diving Swimming and Diving: Schedule Swimming and Diving: Roster Swimming and Diving: News Tennis Tennis: Schedule Tennis: Roster Tennis: News Track and Field Track and Field: Schedule Track and Field: Roster Track and Field: News Volleyball Volleyball: Schedule Volleyball: Roster Volleyball: News Athletics Overview Mission Statement Staff Directory Corporate Partnerships Student-Athlete Alumni Database Media Relations News Archives 2022-23 Media Credential Applications Communication Request Academics and Compliance Advising & Tutoring Student Athlete Handbook Recruiting FAQs Student-Athlete Employment Form COVID-19 Campus Concern Howard Title IX Division of Student Affairs HU Bison Gear Bison Tickets Bison Season Tickets Bison Ticketing Policy Facility Request Form Burr Gymnasium Burr Gymnasium Pool East Capitol Campus (Tennis) Greene Stadium Nationals Youth Academy (Softball) Photo Galleries Bison Live - Live Stream Composite Calendar Social Media Directory Where Are They Now Bison Senior Spotlights Bison Express Athletic Fund Corporate Partnerships HU Golf Endowment Fund Bison Blue Fund Booster FAQs Alumni Fan Guidelines Sport Navigation MenuĪMHERST, Mass. ![]() ![]() ![]() Signal Mountain Lodge is open from approximately May 12 to October 15, 2017.įor reservations, call Signal Mountain Lodge at 30 or Book Online. Other amenities include two restaurants, a tour desk, a convenience store and gas station. The Mountain View Cottage has a large picture window that overlooks the Teton Range making. 21 Ways to Do Summer in Jackson Hole Like A Local Our staff of locals weighs in on some of their. They are carpeted and have lovely handmade pine furniture. Lodging, dining and activities in Grand Teton National Park. Boat rentals are available at Signal Mountain Lodge, which is located at the southern. ![]() The lodge has 80 units, some with beach frontage. Once at the top, you will be treated to beautiful views of the Teton Range, Jackson Lake, and the Snake River, as well as the Teton Valley below. No matter whether you stay in one of the small motel-style cabin units or the family bungalows, you’ll find these accommodations provide a unique atmosphere to your stay. Salaries, reviews, and more - all posted by employees working at Signal Mountain Lodge. Try a guided fishing trip and see what sort of catch you can make.īy choosing Signal Mountain Lodge as your place to stay within Grand Teton, you will discover the rustic beauty of this area is extremely appealing. See what employees say its like to work at Signal Mountain Lodge. Take a scenic float trip on the Snake River. Teton Village, WY Verified - Update Listing Alpine elegance slopeside to Jackson Hole. There are lots of trails nearby where you can hike and watch the wildlife. You can enjoy the water sports that Jackson Lake provides, such as fishing, sailing and kayaking. In the heart of Grand Teton National Park youll find unique lakeside lodging at Signal Mountain Lodge - the only lakefront accommodations in the park. Outdoor fun is abundant for all guests at the lodge. Signal Mountain Lodge WY can be reached by taking Highway 191 to Moose Junction, turning left and driving eighteen miles. Join us for a guided fishing trip on the Snake River through Grand Teton National. The rustic cabins are set on the lakeshore of Jackson Lake at the foot of the Tetons and offer a real getaway experience. Signal Mountain Lodge is open from approximately May 12 to October 15, 2017.įor reservations, call Signal Mountain Lodge at 30 or Book Online.Signal Mountain Lodge Wyoming offers wonderful accommodations for visitors to Grand Teton National Park. Signal Mountain Lodge - Rooms Starting 346. They are carpeted and have lovely handmade pine furniture. Signal Mountain Lodge is one of the only two lodging options located on the shores of Jackson Lake in Grand Teton National Park, offering a variety of comfortable accommodations from comfortable lodge-style rooms to breathtaking lakeside retreats and cozy rustic cabins. The lodge has 80 units, some with beach frontage. Try a guided fishing trip and see what sort of catch you can make.īy choosing Signal Mountain Lodge as your place to stay within Grand Teton, you will discover the rustic beauty of this area is extremely appealing. ![]() Take a scenic float trip on the Snake River. The main building of this lodge on Jackson Lakes southern. There are lots of trails nearby where you can hike and watch the wildlife. Signal Mountain Lodge Rd., Grand Teton National Park, Wyoming, 83013, USA Fodors Choice. You can enjoy the water sports that Jackson Lake provides, such as fishing, sailing and kayaking. Signal Mountain Lodge WY can be reached by taking Highway 191 to Moose Junction, turning left and driving eighteen miles. Signal Mountain Lodge Wyoming offers wonderful accommodations for visitors to Grand Teton National Park. ![]() ![]() ![]() ![]() For more information, visit *6% ABV version of Bud Light Lime ‘Lime-a-Rita’ is available in Maine, Mississippi, New Hampshire, and Tennessee. The company is a wholly-owned subsidiary of Anheuser-Busch InBev, the leading global brewer, and continues to operate under the Anheuser-Busch name and logo. Anheuser-Busch is a major manufacturer of aluminum cans and has been a leading aluminum recycler for more than 30 years. Find quality adult beverage products to order online or add to your Shopping. Anheuser-Busch also owns a 50 percent share in Grupo Modelo, Mexico’s leading brewer. Shop for Ritas Lime-A-Rita Sparkling Margarita (8 fl oz) at Jay C Food Stores. The company brews Budweiser and Bud Light, two of the world’s largest-selling beers. 1, 2018, will also benefit from the settlement’s injunctive relief. Buy Now 8 ABV Ritas Straw-Ber-Rita Malt Beverage RITAS Straw-Ber-Rita has the great taste of a strawberry margarita with a twist of Bud Light Lime for a delightfully refreshing. ![]() ![]() Louis, Anheuser-Busch is the leading American brewer, holding a 47.7 percent share of U.S. Consumers who purchased Lime-A-Rita or related products since Jan. Ritas Lime-A-Rita Sparkling Margarita is a light, refreshing option that's perfect for every occasion. Designed to reflect the current look and feel of Bud Light, the new Bud Light Lime packaging will feature the brand’s iconic green color more prominently.įor more information on Lime-a-Rita and Bud Light Lime, visit or Anheuser-Busch:īased in St. 18, 2022 /PRNewswire/ - A Settlement has been reached in a class action lawsuit filed against Defendant Anheuser-Busch, LLC regarding Lime-A-Rita and other Ritas. The introduction of Lime-a-Rita follows January’s launch of Bud Light Platinum, the best selling new beer of 2012 according to IRI Symphony data.Īs Lime-a-Rita hits the market, Bud Light Lime has also received an updated look with the introduction of new primary and secondary packaging. shrink-wrapped bottles and single-serve 24 oz. The new drink will be available in 12-packs of 8 oz. BC563150, Superior Court of California in the County of Los Angeles).įor more information about other class-action lawsuits filed against Anheuser-Busch LLC and ’s coverage of the company, click here.Lime-a-Rita can be enjoyed from the can or, like the popular cocktail that inspired it, is best served over ice. November 2014: A class-action lawsuit was filed against Anheuser-Busch for allegedly falsely advertising several flavors of Bud Light Lime-A-Rita malt beverages – including the Lime-A-Rita, Raz-Ber-Rita, Straw-Ber-Rita, Mang-O-Rita, and Apple-Ahhh-Rita – as “light” and low-calorie beverages when they actually contain “significantly more calories and carbohydrates than any other Anheuser-Busch alcoholic beverage.” ( Cruz et al v. Browse our wide selection of Flavored Malt Beverages for Delivery or Drive Up. concluding that the plaintiffs did not sufficiently allege that the labels at issue could deceive a reasonable consumer.ĭecember 2014: This action was transferred to federal court. Shop Ritas Lime A Rita Sparkling Margarita Can - 25 Fl. June 2015: A federal judge dismissed this action When a complaint is dismissed with prejudice, it cannot be refiled. July 2015: The plaintiffs filed a Notice of Appeal regarding the June 2015 dismissal order. The appellate court found that reasonable consumers would not be deceived into thinking that Bud Light Lime-a-Rita is a low-calorie, low-carbohydrate beverage because the label makes clear that the beverage is not a “normal beer.” Later in March, plaintiffs filed a petition for en banc review (i.e., a rehearing by all of the judges of the Ninth Circuit, rather than the selected three-judge panel.) March 2017: The Ninth Circuit Court of Appeals affirmed the District Court’s decision to dismiss the lawsuit. April 2017: Plaintiffs’ petition for en banc review was denied. ![]() ![]() ![]() To create the hinges of the right side, you need to go above the vehicle because of the orientation of the already created hinges. Simply start adding hinges to the left until you reach the already created hinges. Now add a wheel under it so your hinges go in line with the vehicle wheels. So once you are on the other side, the method is pretty much the same as with the left side, add blocks until you are in line with the wheels on the blue axis A Besiege (BSG) Mod in the Crafting Contest category. If you decide to question your glorious lord, this will happen Heavy tank with four treads, rapid-fire double fireball cannon, bomb launcher turret, cannon turret. Since we can't rotate hinges upside down, only to the side, you are forced to go around and connect the rest of them from the other side. to assail or ply, as with requests or demands. I have to admit I do enjoy my zombie stories to be. Now in order to create the lower and right side, you have to go to the other side of your vehicle. to crowd around crowd in upon surround: Vacationers besieged the travel office. Oasis treads classic Romero-esque ground and has a suitably downbeat ending that I really enjoyed. ![]() It has to look exactly like this, otherwise it won't be it. When you connect the final hinge, your loop will be complete. Now we gotta create the left side, remember we are creating a perfect loop of hinges and that is impossible by just connecting them one after another perpendicularlyĪdd a block going down (you have to go down because of the hinge orientation) and then attach a wheel, we need to go half a block to the right so we are right next to the wheel and so the upper hinge connects properly to the hinges you are creating.Īfter adding another block, you'll see that you're in a perfect positionĪdd hinges up, you will encounter a problem with the already created hinges, just delete the extra one When you add hinges, you have to pay attention to their orientation. ![]() There is a submission form for machines and a database table with downloads of all machines that were submitted so far.Īll of my info is available below if you happen to be interested. I'm a big fan of Besiege and I have a section on my website dedicated to the game. The internet calls me Petard, I'm a Croatian youtuber and a very active Besiege community person! I have several other Besiege guides that you can view below: ![]() ![]() ![]() To learn more about how and for what purposes Amazon uses personal information (such as Amazon Store order history), please visit our Privacy Notice. Depending on who you ask, the Golden State is a bellwether for progress, or a liberal hellscape. You can change your choices at any time by visiting Cookie Preferences, as described in the Cookie Notice. ![]() It allows single or multiple players to pass footballs to any surface and receive the ball back at different. Click ‘Customise Cookies’ to decline these cookies, make more detailed choices, or learn more. Great for improving players crucial core skills. Learn more 18+, T&C apply, Credit subject to status. Fast and free shipping free returns cash on delivery available on eligible purchase. Hand Held Rebounder - Football Flick Rated 4.75 out of 5 based on 4 customer ratings ( 4 customer reviews) Hand Held Rebounder Improve your reaction speeds 44.99 Add to cart FREE 12 month Warranty Trusted Delivery Partners Secure Checkout Designed in the UK Make 3 payments of 14.99. Third parties use cookies for their purposes of displaying and measuring personalised ads, generating audience insights, and developing and improving products. Buy Football Flick Urban Skills Rebounder and Net 4 In 1 Football Training Equipment Scientifically Validated Used By Premier League Academies online on Amazon.ae at best prices. This includes using first- and third-party cookies, which store or access standard device information such as a unique identifier. Football Flick Urban Skills Training Rebounder and Net £130.00 Hy-Pro UEFA Champions League Size 5 Football £12.00 Total price: £142.00 Add all items to trolley About this product The first trainer to be scientifically validated to improve players core skills by up to 73. If you agree, we’ll also use cookies to complement your shopping experience across the Amazon stores as described in our Cookie Notice. We also use these cookies to understand how customers use our services (for example, by measuring site visits) so we can make improvements. Its ideal for testing distance accuracy and close control to feet, chest, head and thighs. It can also be adjusted across 6 different angle positions for varied returns. We use cookies and similar tools that are necessary to enable you to make purchases, to enhance your shopping experiences and to provide our services, as detailed in our Cookie Notice. Youngsters can train like a pro with this Football Flick Dual Speed Rebounder This 85 x 85cm dual-sided rebounder comes with both medium and fast return speeds to choose from. ![]() ![]() ![]() ![]() In Germany and Austria rules over LinkedIn. Only 3 percent of the labor market in Germany, Poland, and Austria and 4 percent of the labor market in Czech Republic evaluates LinkedIn as the preferred social media recruitment channel. LinkedIn in Asia, East Europe, and OceaniaĪccording to the data of Intelligence Group and, LinkedIn is in some parts of the world very strong, but in others parts less so. The battle of global recruitment goes further and is bigger than the Netherlands, UK, and the U.S. What does this information tell us? Is LinkedIn the strongest channel and the overall winner? No. That would be too easy: more insights are needed. Of the 132.5 million visitors to Indeed, 60 percent comes from the United States.Īlso: both are not sending a lot of traffic to each other Indeed and LinkedIn are not each major referring or destination sites to each other. Looking at the 607.5 million visitors of LinkedIn, 38 percent of the traffic comes from the United States. In addition, when we take a look at the data provided by of both recruitment channels (LinkedIn and Indeed), there is a big difference in the traffic toward LinkedIn versus Indeed. So LinkedIn is still dominant over Indeed but the gap with Indeed in closing fast in its most dominate markets.įor a total view of the scores of both recruitment channels in all 45 countries take a look at this. In the Netherlands LinkedIn scores two times better than Indeed, in the United Kingdom 1.1 times, and in the United States LinkedIn scores 1.4 times better than Indeed. The figures illustrate the relationship that LinkedIn has to Indeed based on the scores on the question “most preferable recruitment channel.” Worldwide LinkedIn scores 2.5 times better than Indeed. The difference between the channels LinkedIn and Indeed with regards to the scores on the question “preferable recruitment channel” is small, especially, in comparison with their rankings in the United Kingdom and United States (see the three figures illustrated below). and fourth in the United Kingdom and Netherlands as the most preferred job board. According to data from Intelligence Group, Indeed is positioned second in the U.S. Indeed is gaining market share in some of the top markets of LinkedIn. Indeed Grows Strong in the “Homelands” of LinkedIn In which countries do they have the largest market share? Who of the two shows the strongest growth? Who beats who in the battle for global recruitment domination? Choosing LinkedIn Over Indeed as Preferred Recruitment ChannelĪccording to the Global Talent Acquisition Monitor, a large scale international research executed by Intelligence Group in 45 countries, 87 percent of the labor force in the measured countries would prefer LinkedIn over Indeed as their preferred recruitment channel. Both evolved into global recruitment channels that are more extended and complete than ever before. Indeed vs LinkedIn: What is the Status?īoth are frontrunners, pioneers, and innovators in developing services that are a new way of doing (international) recruitment. In this article we use data from, , and Intelligence Group to make a comparison between the strengths of Indeed and LinkedIn, in core of the global workforce. Is LinkedIn moving from the largest social business network where people can source, refer, connect, and interact with each other to the largest job board with a lots of other features as well? LinkedIn has decided to extend its recruitment channel by aggregating job listings from other sources. Besides aggregating as many jobs as possible it is moving to a global organization that focuses on providing advice, resumes, and recruitment data … a salary survey where you can search and compare salaries from over 5 million functions, a resume database which contains over millions of resumes, a job trend page, an employer referrals section, and blogs where Indeed shares trendy recruitment information.Īfter LinkedIn announced that companies can create showcase pages to promote their business, it is now time for the job seekers themselves. It is not focusing on a single service anymore. Indeed, as the biggest job aggregator, recently entered the stock market. Indeed and LinkedIn can be seen as two recruitment channels that have changed the status quo in the market. With a presence in 50 countries, 28 languages, millions of CVs, and at least 140 million job seekers monthly, Indeed seems to be the biggest competitor and the first player that really gives access to the complete global market. But there is competition from a new kid on the block. With over 300 million profiles and presence in 200 countries, LinkedIn seems to be the dominant player for global recruitment. ![]() ![]() CSVD accounts for 50–70% of vascular cognitive impairment cases and 45% of dementia cases and results in a heavy social burden ( 2).Ĭhronic insomnia, the most common sleep disorder in elderly individuals, is often comorbid with physical diseases including cerebral vascular disease ( 3). Considering the high incidence of insomnia in CSVD patients, the results of this preliminary study support the use of low-dose trazodone to deal with insomnia and cognitive impairment in CSVD.Ĭerebral small vessel disease (CSVD) refers to the syndrome of clinical, cognitive, imaging, and pathological manifestations caused by various small vascular diseases ( 1), among which arteriosclerotic CSVD is the most common type ( 1). The improvement of cognition could be achieved by alleviation of insomnia severity. The improvement of sleep quality was correlated with increased concentration and recall abilities.Ĭonclusions: A low dose of trazodone seems acceptable and effective in reducing insomnia severity and improving concentration and recall abilities in this pilot study. ![]() Results: Trazodone caused significantly better improvements in concentration and recall abilities, measured with MoCA, as well as in PSG parameters such as sleep efficiency, N3 sleep ratio, and sleep continuity than the placebo, with no significant differences in the occurrence of side effects. Secondary outcomes included sleep parameters measured with polysomnography (PSG) and the Pittsburgh Sleep Quality Index. The primary outcome was the cognitive score on the Montreal Cognitive Assessment scale (MoCA). Participants were randomized individually to receive either trazodone (study group) or a placebo (control group) for 4 weeks. Forty patients suffering from arteriosclerotic CSVD and insomnia were recruited from an outpatient clinic. Methods: This was a randomized, double-blind, placebo-controlled pilot study. This study was performed to explore the effects of trazodone on sleep quality and cognitive function in CSVD comorbid with chronic insomnia. Low-dose trazodone is effective in treating insomnia, but it is unclear whether it can also improve cognitive function in CSVD patients.
![]() ![]() Intrathoracic pressure becomes even more negative to fill the lungs with air.Inspiratory muscles (mainly external intercostal muscles and the diaphragm) elevate the ribs and sternum and increase the intrathoracic volume.Inspiration of air into the conducting zone of the respiratory tree ( anatomic dead space): nose → pharynx → larynx → trachea → bronchi → bronchioles → terminal bronchioles.Definition: movement of air through the respiratory tract into (inspiration) and out of (expiration) the respiratory zone ( lungs) to facilitate gas exchange (O 2 and CO 2).Inspiration is an active process driven by the respiratory musculature while expiration is passive at rest, driven by the elastic properties of lung tissue. Central regulation of respiration is provided by the respiratory center located in the reticular formation of the medulla oblongata and pons. CO 2 diffuses into the alveoli and is exhaled. In the capillaries, oxygen binds to hemoglobin in erythrocytes or dissolves into the plasma (oxygenation). The gases diffuse across the barrier following pressure gradients. Gas exchange occurs via simple diffusion across the blood-air barrier. Diseases that affect the perfusion (e.g., pulmonary embolism) or ventilation (e.g., foreign body aspiration) can cause a V/Q mismatch. The Euler-Liljestrand mechanism regulates the perfusion of nonventilated alveoli: if a lung section is perfused but not ventilated, there will be a drop in the oxygen concentration in the blood, resulting in hypoxic vasoconstriction. The ventilation-perfusion ratio is higher in the apex of the lung than at its base. Perfusion of the pulmonary capillaries is closely regulated to match ventilation in order to maximize gas exchange. ![]() The physiologic dead space is the volume of inspired air that does not participate in gas exchange. Ventilation is the movement of air through the respiratory tract into (inspiration) and out of (expiration) the respiratory zone ( lungs). The main function of the respiratory system is gas exchange (O 2 and CO 2). ![]() |
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